The main goal of this study was to develop a stable formulation of antibiotic drug Azithromycin as an immediate-release tablet. The task of developing immediate release tablet is accomplished by using a suitable diluents and super-disintegrant. Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time. Microcrystalline cellulose PH 102 was used as diluents. Povidone was used as the binder. Crosscarmellose sodium and pre gelatinized starch was added as a disintegrating agent. Talc and magnesium stearate was used as the lubricant. The prepared granules were compressed into a compression machine. To evaluate the formulated tablets as per requirements of standards. The tablets thus formulated showed satisfactory physical parameters. Evaluation Parameters Like weight variation, hardness of the tablet, friability, thickness, disintegration test, drug content uniformity and in vitro release studies were performed. To optimize the trial batch by 32 full factorial design study and determined the best batch by in vitro release studies are showed that optimization formulation (OF7) was 101.62% respectively. The optimized formulation is further selected and compared with the release profile of the innovator product. The results suggest the feasibility of developing immediate tablets consisting of Azithromycin for the convenience of patients with respiratory infections, gonorrhoea, community-acquired pneumonia, pelvic inflammatory disease, paediatric otitis media and pharyngitis and Mycobacterium avium complex (MAC) in patients with advanced HIV disease.
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